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Commissariat à l'Énergie Atomique (Coordinator)

Commissariat à l'Énergie Atomique (Coordinator)

#1 - Service d’étude des prions et des infections atypiques

Dr Jean-Philippe Deslys

Contact

Team Leader: Dr Jean-Philippe Deslys
18, route du Panorama
Fontenay-aux-Roses, 92265, France
Contact:
Tel: +33 (0) 1 46 54 82 79
Fax: +33 (0) 1 46 54 93 19
E-mail: jpdeslys@cea.fr
Institute website: http://www.cea.fr/english_portal

Main area of research

  • Decontamination: development, Optimization and Validation of new protocols and procedures to decontaminate prions and other highly resistant agents.

  • Physiopathology: molecular and cellular mechanisms of cellular susceptibility to infection / physiopathology and risk assessment of prion diseases through rodent and primate experimental models.

  • Therapeutic: screening and evaluation of new anti amyloid compounds, in vitro and in vivo evaluations of heparan mimetics derived.

Research Team

  • Researchers: 6
  • Technicians: 9
  • Postdocs: 0
  • PhD/MD Students: 3

Facility Picture

Facilities and Equipment

  • Laboratories: BSL1, BSL2, BSL3
  • General equipment: Microbiology, Cell Biology, Cell culture, Pathology, Neurobiology, Biochemistry, Molecular biology, Histology, Imaging, Risk assessment
  • Special equipment: Cell sorter, Confocal microscopy, PMCA equipments
  • Specific methods: Specific procedures to evaluate protocols for inactivation and/or elimination of prion, purification and detection techniques of prion in biological samples

Main references

  • Larramendy-Gozalo C, Barret A, Daudigeos E, Mathieu E, Antonangeli L, Riffet C, Petit E, Papy-Garcia D, Barritault D, Brown P, Deslys JP. Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseases. J Gen Virol. 2007 Mar;88(Pt 3):1062-7.
  • Lasmézas CI, Comoy E, Hawkins S, Herzog C, Mouthon F, Konold T, Auvré F, Correia E, Lescoutra-Etchegaray N, Salès N, Wells G, Brown P, Deslys JP. Risk of oral infection with bovine spongiform encephalopathy agent in primates. Lancet. 2005 Feb 26-Mar 4;365(9461):781-3.
  • Fichet G, Comoy E, Duval C, Antloga K, Dehen C, Charbonnier A, McDonnell G, Brown P, Lasmézas CI, Deslys JP. Novel methods for disinfection of prion-contaminated medical devices. Lancet. 2004 Aug 7-13;364(9433):521-6.
  • Barret A, Tagliavini F, Forloni G, Bate C, Salmona M, Colombo L, De Luigi A, Limido L, Suardi S, Rossi G, Auvré F, Adjou KT, Salès N, Williams A, Lasmézas C, Deslys JP. Evaluation of quinacrine treatment for prion diseases. J Virol. 2003 Aug;77(15):8462-9.
  • Deslys JP, Comoy E, Hawkins S, Simon S, Schimmel H, Wells G, Grassi J, Moynagh J. Screening slaughtered cattle for BSE. Nature. 2001 Jan 25;409(6819):476-8.

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