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Institut National de la Recherche Agronomique

Institut National de la Recherche Agronomique

#2 - Unité de Virologie Immunologie Moléculaires (VIM)

Dr. Hubert Laude


Team Leader: Dr. Hubert Laude
U892 Virologie Immunologie Moléculaires - Domaine de Vilvert
Jouy en Josas, 78350, France
Contact: Dr. Hubert Laude
Tel: +33 (0) 1 34 65 26 00
Fax: +33 (0) 1 34 65 26 21
Institute website:

Main area of research

  • Prion biology in cell culture models

  • Prion diversity in transgenic mousemodels

  • Prion strains and species barrier

Research Team Picture

Research Team

  • Researchers: 3
  • Technicians: 3
  • Postdocs: 1
  • PhD/MD Students: 2

Facility Picture

Facilities and Equipment

  • Laboratories: BSL1, BSL2, BSL3

  • General equiment: Microbiology, Cell Biology, Cell culture, Neurobiology, Immunology, Biochemistry, Molecular biology, Biophysics

Main references

  • Béringue V, Le Dur A, Tixador P, Reine F, Lepourry L, Perret-Liaudet A, Haïk S, Vilotte JL, Fontés M & Laude H. (2008). Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD. PLoS ONE 3, e1419.
  • Cronier S, Beringue V, Bellon A, Peyrin JM & Laude H. (2007). Prion strain- and species-dependent effects of antiprion molecules in primary neuronal cultures. J Virol. 81, 13794-800.
  • Béringue V, Andréoletti O, Le Dur A, Essalmani R, Vilotte JL, Lacroux C, Reine F, Herzog L, Biacabé AG, Baron T, Caramelli M, Casalone C & Laude H.( 2007). A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission. J Neurosci. 27, 6965-71.
  • Beringue V, Bencsik A, Le Dur A, Reine F, Lai TL, Chenais N, Tilly G, Biacabe AG, Baron T, Vilotte JL & Laude H. (2006). Isolation from cattle of a prion strain distinct from that causing bovine spongiform encephalopathy. PLoS Pathog. 2, e112.
  • Le Dur A, Beringue V, Andreoletti O, Reine F, Lai TL, Baron T, Bratberg B, Vilotte JL, Sarradin P, Benestad SL & Laude H. (2005). A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proc Natl Acad Sci U S A. 102, 16031-6.

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