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Agence Française de Sécurité Sanitaire des Aliments

Agence Française de Sécurité Sanitaire des Aliments

#3 - Virology-ATNC

Dr. Thierry Baron


Team Leader: Dr. Thierry Baron
31 avenue Tony Garnier
Lyon, 69364 CEDEX 07, France
Contact: Thierry Baron
Tel: +33 (0) 4 78 72 65 43
Fax: +33 (0) 4 78 61 91 45
Institute website:

Main area of research

  • Diagnosis and surveillance of prion diseases in ruminants: national reference laboratory
  • Strain typing: discrimination of prion strains by molecular studies of the disease-associated prion protein and bioassays in wild type and transgenic rodent

Research Team

  • Researchers: 5
  • Technicians: 10
  • Postdocs: 0
  • PhD/MD Students: 3

Facility Picture

Facilities and Equipment

  • Laboratories: BSL1, BSL2, BSL3
  • General equipment: Microbiology, Cell Biology, Cell culture, Pathology, Biochemistry, Molecular biology, Histology, Epidemiology

Main references

  • Baron T, Bencsik A, Biacabe A-G, Morignat E and Bessen RA. Phenotypic similarity of transmissible mink encephalopathy in cattle and L-type bovine spongiform encephalopathy in a mouse model. Emerg. Infect. Dis., 13: 1887-1894, 2007.
  • Baron T and Biacabe A-G. Molecular behaviors of «CH1641-like» sheep scrapie isolates in ovine transgenic mice (TgOvPrP4). J. Virol., 81: 7230-7237, 2007.
  • Bencsik A and Baron T. Bovine spongiform encephalopathy agent in a prion protein (PrP) ARR/ARR genotype sheep after peripheral challenge: complete immunohistochemical analysis of disease-associated PrP and transmission studies to ovine transgenic mice. J. Infect. Dis., 195: 989-996, 2007.
  • Jacobs J, Langeveld J, Biacabe A-G, Acutis P-L, Polak M, Gavier-Widen D, Buschmann A, Caramelli M, Casalone C, Mazza M, Groschup M, Erkens JHF, Davidse A, van Zijderveld FG and Baron T. Molecular discrimination of atypical bovine spongiform encephalopathy strains from a geographical region spanning a wide area in Europe. J. Clin. Microbiol., 45:1821-1829, 2007.
  • Arsac J-N, Andreoletti O, Bilheude J-M, Lacroux C, Benestad SL and Baron T. Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway. Emerg. Infect. Dis., 13: 58-65, 2007.

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