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Centre National de la Recherche Scientifique

Centre National de la Recherche Scientifique

#4 - Institut de génétique humaine

Prof  Sylvain Lehmann


Team Leader: Prof Sylvain Lehmann
141, rue de la Cardonille
Montpellier, 34396, France
Contact: Prof. Sylvain Lehmann
Tel: +33 499619931
Fax: +33 499619901
Institute website:

Main area of research

  • use of cell culture models: transmission of prions, detection of infectivity, decontamination
  • proteomics: surrogate markers of TSEs
  • gene and cell therapy: cell therapy using genetically modified stem cells

Research Team

  • Researchers: 5
  • Technicians: 2
  • Postdocs: 2
  • PhD/MD Students: 2

Facility Picture

Facilities and Equipment

  • Laboratories: BSL1, BSL2, BSL3
  • General equipment: Microbiology, Cell Biology, Cell culture, Pathology, Neurobiology, Immunology, Biochemistry, Chemistry, Molecular biology, Histology, Imaging
  • Special equipment: SELDI-TOF, proteomics (2D…)
  • Specific methods: Culture of embryonic stem cells, cell graft, proteomics

Main references

Roche S., Gabelle A. & Lehmann S. (2008) Clinical Proteomics of the Cerebrospinal Fluid: towards the discovery of new biomarkers. Proteomics Clin. Appl. 2, 428–436.
Prior M., Lehmann S., Sy MS, Molloy B. and McMahon H.E.M (2007) Cyclodextrins inhibit replication of scrapie prion protein in cell culture. J. Virol 81:11195-207.
Solassol J., Pastore M., Crozet C. Perrier V. & Lehmann S. (2006) A novel copper – hydrogen peroxide formulation for prion decontamination. J Infect Dis. 194:865-9.
Milhavet O., Casanova D., Chevallier N., McKay R.D.G & Lehmann S. (2006) Neural stem cell model for prion propagation. Stem Cells 24:2284-91.
Crozet C., Lin Y.-L., Mettling C., Mourton-Gilles C., Corbeau P., Lehmann S. & Perrier V. (2004) Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations. Journal of Cell Science 117:5591-7.

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