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Heinrich-Heine-Universitäte-Düsseldorf

Heinrich-Heine-Universitäte-Düsseldorf

#12 - Prion research group

Prof. Detlev Riesner

Contact

Team Leader: Prof. Detlev Riesner
Universitätsstr. 1
Düsseldorf, 40225, Germany
Contact: Prof. Detlev Riesner
Tel: +49 211 81 11390
Fax: +49 211 81 15167
E-mail: riesner@biophys.uni-duesseldorf.de
Institute website: http://www.biologie.uni-duesseldorf.de/englisch

Main area of research

  • Diagnosis
  • Decontamination
  • Basic research

Research Team

  • Researchers: 7
  • Technicians: 3
  • Postdocs: 3
  • PHD/MD Students: 3

Facilities and Equipment

  • Laboratories: BSL1, BSL2, BSL3
  • General equipment: Biochemistry, Molecular biology, Biophysics, Histology, Imaging
  • Special equipment: analytical ultracentrifuge, 2-colour fluorescence spectrometer (FCS) with imaging, circular dichroism spectrometer, surface plasmon resonance (Biacore), fluorescence spectrometer, high pressure incubator for temperatures up to 200 °C. All instruments are within the BSL3-facility
  • Specific methods: In vitro misfolding assays, PrPC from CHO-culture, PrP-membrane interaction, diagnosis by surface-FIDA

Main references

  • Elfrink K, Ollesch J, Stöhr J, Willbold D, Riesner D & Gerwert K (2008). Structural changes of membrane anchored native PrPC. Proc Natl AcadSci USA - in print.
  • Stöhr J, Weinmann N, Wille H, Kaimann T, Nagel-Steger L, Birkmann E, Panza G, Prusiner SB, Eigen M & Riesner D. (2008). Mechanisms of prion protein assembly into amyloid. Proc Natl Acad Sci USA, 105(7), 2409-2414.
  • Kaimann T, Metzger S, Kuhlmann K, Brandt B, Birkmann E, Höltje HD & Riesner D. (2008). Molecular model of an alpha-helical prion protein dimer and its monomeric subunits as derived from chemical cross-linking and molecular modeling calculations. J Mol Biol., 376(2), 582-596.
  • Birkmann E, Henke F, Weinmann N, Dumpitak C, Groschup M, Funke A, Willbold D & Riesner D. (2007). Counting of single prion particles bound to a capture-antibody surface (surface-FIDA). Vet Microbiol, 123(4), 294-304.
  • Mu.ller H, Stitz L, Wille H, Prusiner SB, Riesner D. (2007). Influence of water, fat, and glycerol on the mechanism of thermal prion inactivation. J Biol Chem, 282(49), 35855-35867.

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