Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health
#14 - Institute for Novel and Emerging Infectious Diseases
Contact
Team Leader: Prof. Martin H. Groschup
Boddenblick 5a Greifswald
Insel Riems, 17493, Germany
Contact: Prof. Martin H. Groschup
Tel: +49 383517163
Fax: +49 383517191
E-mail: martin.groschup@fli.bund.de
Institute website:
http://www.fli.bund.de/4+M52087573ab0.html
Main area of research
- BSE / scrapie diagnosis and pathogenesis
- Prion strains (incl. atypicals)
- PrP cell free conversion, PMCA and tissue culture
Research Team
- Researchers: 3
- Technicians: 3
- Postdocs: 1
- PhD/MD Students: 8
Facilities and Equipment
- Laboratories: BSL3
- General equipment: Microbiology, Cell Biology, Cell culture, Pathology, Neurobiology, Biochemistry, Chemistry, Molecular biology, Histology, Epidemiology, Risk assessment
Main references
- Groschup MH, Lacroux C, Buschmann A, Lu.hken G, Mathey J, Eiden M, Lugan S, Hoffmann C, Espinosa JC, Baron T, Torres JM, Erhardt G, Andreoletti O (2007) Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France. Emerging Infectious Diseases, 13: 1201-7
- Hoffmann, C, Ziegler, U, Buschmann, A, Weber, A, Kupfer, A, Oelschlegel, A, Hammerschmidt, B and Groschup, M.H. (2007) BSE prions spread via the autonomous nervous system from the gut to the CNS in incubating bovines. J. Gen. Virol. 88: 1048-55
- Gretzschel, A., Buschmann, A., Langeveld, J. and Groschup, M.H. (2006) Immunological Characterization of abnormal prion protein from atypical scrapie cases in sheep using a panel of monoclonal antibodies. J. Gen. Virol 87: 3715-22.
- Buschmann, A., Gretzschel, A, Biacabe, A.G., Corona, C., Hoffmann, C., Eiden, M., Baron, T., Caramelli, M., Conraths, F.J. and Groschup, M.H. (2006) Atypical BSE cases in Germany - proof of transmissibility and biochemical characterization. Veterinary Microbiology, 117: 103-16
- Buschmann A, Groschup MH (2005) Highly BSE sensitive transgenic mice confirm essential restriction of infectivity to the nervous system in clinically diseased cattle. J. Infect. Dis. 192:934-42
- Neuendorf E, Weber A, Saalmuller A, Schatzl H, Reifenberg K, Pfaff E, Groschup MH (2004) Glycosylation deficiency at either one of the two glycan attachment sites of cellular prion protein preserves susceptibility to BSE and scrapie infections. J Biol Chem. 279:53306-16
