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Centraal Instituut voor Dierziekte Controle-Lelystad

Centraal Instituut voor Dierziekte Controle-Lelystad




Team Leader: Alex BOSSERS
Edelhertweg 15
Lelystad, 8219 PH, The Netherlands
Contact: Dr. Jan Langeveld
Tel: +312 320 238238
Fax: +312 320 238153
Institute website:

Main area of research

  • Ruminant TSEs surveillance & diagnosis
  • Epidemiology & risk
  • Prion biology and genetics

Research Team Picture

Research Team

  • Researchers: 7
  • Technicians: 9
  • Postdocs: -
  • PhD/MD Students: 1

Facility Picture

Facilities and Equipment

  • Laboratories: BSL1, BSL2, BSL3
  • General equipment: Microbiology, Cell culture, Pathology, Immunology, Biochemistry, Chemistry, Molecular biology, Histology, Epidemiology, Risk assessment
  • Special equipment: Typhoon imager, PMCA equipment, monoclonal production facilities, microarraying, multiplexing, Ciphergen instrumentation, Pepscan system in short reach
  • Specific methods: sheep micro array, epitope mapping, PrP-conversion technology, PVDF-binding assays, PrPres removal

Main references

  • Capobianco R, Casalone C, Suardi S, Mangieri M, Miccolo C, Limido L, Catania M, Rossi G, Di Fede G, Giaccone G, Bruzzone MG, Minati L, Corona C, Acutis P, Gelmetti D, Lombardi G, Groschup MH, Buschmann A, Zanusso G, Monaco S, Caramelli M, Tagliavini F. (2007). Conversion of the BASE prion strain into the BSE strain: the origin of BSE? PLoS Pathog. 3, e31
  • Soto C, Anderes L, Suardi S, Cardone F, Castilla J, Frossard MJ, Peano S, Saa P, Limido L, Carbonatto M, Ironside J, Torres JM, Pocchiari M, Tagliavini F. (2005). Pre-symptomatic detection of prions by cyclic amplification of protein misfolding. FEBS Lett. 579, 638-42.
  • Forloni G, Iussich S, Awan T, Colombo L, Angeretti N, Girola L, Bertani I, Poli G, Caramelli M, Grazia Bruzzone M, Farina L, Limido L, Rossi G, Giaccone G, Ironside JW, Bugiani O, Salmona M, Tagliavini F. (2002) Tetracyclines affect prion infectivity. Proc Natl Acad Sci U S A 99, 10849-54
  • Puoti G, Giaccone G, Rossi G, Canciani B, Bugiani O, Tagliavini F. (1999) Sporadic Creutzfeldt-Jakob disease: co-occurrence of different types of PrP(Sc) in the same brain. Neurology 53, 2173-6.
  • Tagliavini F, McArthur RA, Canciani B, Giaccone G, Porro M, Bugiani M, Lievens PM, Bugiani O, Peri E, Dall’Ara P, Rocchi M, Poli G, Forloni G, Bandiera T, Varasi M, Suarato A, Cassutti P, Cervini MA, Lansen J, Salmona M, Post C. (1997) Effectiveness of anthracycline against experimental prion disease in Syrian hamsters. Science 276, 1119-22

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