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Istituto Nazionale Neurologico Carlo Besta

Istituto Nazionale Neurologico Carlo Besta


Dr. Fabrizio Tagliavini


Team Leader: Dr. Fabrizio Tagliavini
via Celoria 11
Milano, 20133, Italy
Contact: Dr. Fabrizio Tagliavini
Tel: +39 02 23942260
Fax: +39 02 23942101
Institute website:

Main area of research

  • Therapeutic: In vitro and in vivo evaluation of anti-prion compounds; clinical trial in humans with doxycycline
  • Physiopathology: Characterization of biological properties of natural and experimental prion strains in inbred and transgenic mice
  • Neuropathology: Characterization of neuropathological and molecular phenotype of human prion disease

Research Team Picture

Research Team

  • Researchers: 15
  • Technicians: 3
  • Postdocs: 8
  • PhD/MD Students: 2

Facilities and Equipment

  • Laboratories: BSL1, BSL2, BSL3
  • General equipment: Cell Biology, Cell culture, Pathology, Neurobiology, Biochemistry, Molecular biology, Histology, Imaging
  • Special equipment: PMCA equipment, 2D gel electrophoresis, Electro-microscope, Atomic force microscope, Confocal microscopy

Main references

  • Capobianco R, Casalone C, Suardi S, Mangieri M, Miccolo C, Limido L, Catania M, Rossi G, Di Fede G, Giaccone G, Bruzzone MG, Minati L, Corona C, Acutis P, Gelmetti D, Lombardi G, Groschup MH, Buschmann A, Zanusso G, Monaco S, Caramelli M, Tagliavini F. (2007). Conversion of the BASE prion strain into the BSE strain: the origin of BSE? PLoS Pathog. 3, e31
  • Soto C, Anderes L, Suardi S, Cardone F, Castilla J, Frossard MJ, Peano S, Saa P, Limido L, Carbonatto M, Ironside J, Torres JM, Pocchiari M, Tagliavini F. (2005). Pre-symptomatic detection of prions by cyclic amplification of protein misfolding. FEBS Lett. 579, 638-42.
  • Forloni G, Iussich S, Awan T, Colombo L, Angeretti N, Girola L, Bertani I, Poli G, Caramelli M, Grazia Bruzzone M, Farina L, Limido L, Rossi G, Giaccone G, Ironside JW, Bugiani O, Salmona M, Tagliavini F. (2002) Tetracyclines affect prion infectivity. Proc Natl Acad Sci U S A 99, 10849-54
  • Puoti G, Giaccone G, Rossi G, Canciani B, Bugiani O, Tagliavini F. (1999) Sporadic Creutzfeldt-Jakob disease: co-occurrence of different types of PrP(Sc) in the same brain. Neurology 53, 2173-6.
  • Tagliavini F, McArthur RA, Canciani B, Giaccone G, Porro M, Bugiani M, Lievens PM, Bugiani O, Peri E, Dall’Ara P, Rocchi M, Poli G, Forloni G, Bandiera T, Varasi M, Suarato A, Cassutti P, Cervini MA, Lansen J, Salmona M, Post C. (1997) Effectiveness of anthracycline against experimental prion disease in Syrian hamsters. Science 276, 1119-22.

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