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Medical University of Vienna

Medical University of Vienna

#22 - Institute of Neurology

Prof. Herbert Budka

Contact

Team Leader: Prof. Herbert Budka
AKH4J Waehringer Guertel 18-20
Vienna, 1097, Austria
Contact: Prof. Herbert Budka
Tel: +43 1 40400 5500
Fax: +43 1 40400 5511
E-mail: herbert.budka@meduniwien.ac.at
Institute website: http://www.meduniwien.ac.at/kin/Englische%20Version/institut/eindexinstitut.html

Main area of research

  • Pathogenesis of prion diseases: transport of prions, neuronal vulnerability & cytopathobiology, cell death mechanisms; in comparative approach between experimental models and human tissue
  • Diagnostics of human prion diseases: epidemiology, CSF & blood markers, neuropathology, genetics
  • Comparison of prion diseases with other neurodegenerative and infectious diseases

Research Team Picture

Research Team

  • Researchers: 6
  • Technicians: 14,5
  • Postdocs: 4
  • PhD/MD Students: 12

Facility Picture

Facilities and Equipment

  • Laboratories: BSL1, BSL2, BSL3
  • General equipment: Cell Biology, Cell culture, Pathology, Neurobiology, Immunology, Biochemistry, Chemistry, Molecular biology, Histology, Epidemiology, Risk assessment

Main references

  • Kovács GG, Budka H (2008) Prion diseases: from protein to cell pathology. Am J Pathol 172: 555-565
  • Kovács GG, Gelpi E, Ströbel T, Ricken G, Nyengaard JR, Bernheimer H, Budka H (2007) Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol 66: 628-636
  • Kovács GG, Preusser M, Strohschneider M, Budka H (2005) Subcellular localization of disease associated prion protein in the human brain. Am J Pathol 166: 287-294
  • Kovács GG, Head MW, Hegyi I, Bunn TJ, Flicker H, Hainfellner JA, McCardle L, László L, Jarius C, Ironside JW, Budka H (2002) Immunohistochemistry for the prion protein: comparison of different monoclonal antibodies in human prion disease subtypes. Brain Pathol 12: 1-11
  • Hainfellner JA, Brantner-Inthaler S, Cervenáková L, Brown P, Kitamoto T, Tateishi J, Diringer H, Liberski PP, Regele H, Feucht M, Mayr N, Wessely P, Summer K, Seitelberger F, Budka H (1995) The original Gerstmann-Sträussler-Scheinker family of Austria: divergent clinicopathological phenotypes but constant PrP genotype. Brain Pathol 5: 201-211

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