Medical University of Vienna
#22 - Institute of Neurology
Contact
Team Leader: Prof. Herbert Budka
AKH4J Waehringer Guertel 18-20
Vienna, 1097, Austria
Contact: Prof. Herbert Budka
Tel: +43 1 40400 5500
Fax: +43 1 40400 5511
E-mail: herbert.budka@meduniwien.ac.at
Institute website:
http://www.meduniwien.ac.at/kin/Englische%20Version/institut/eindexinstitut.html
Main area of research
- Pathogenesis of prion diseases: transport of prions, neuronal vulnerability & cytopathobiology, cell death mechanisms; in comparative approach between experimental models and human tissue
- Diagnostics of human prion diseases: epidemiology, CSF & blood markers, neuropathology, genetics
- Comparison of prion diseases with other neurodegenerative and infectious diseases
Research Team
- Researchers: 6
- Technicians: 14,5
- Postdocs: 4
- PhD/MD Students: 12
Facilities and Equipment
- Laboratories: BSL1, BSL2, BSL3
- General equipment: Cell Biology, Cell culture, Pathology, Neurobiology, Immunology, Biochemistry, Chemistry, Molecular biology, Histology, Epidemiology, Risk assessment
Main references
- Kovács GG, Budka H (2008) Prion diseases: from protein to cell pathology. Am J Pathol 172: 555-565
- Kovács GG, Gelpi E, Ströbel T, Ricken G, Nyengaard JR, Bernheimer H, Budka H (2007) Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol 66: 628-636
- Kovács GG, Preusser M, Strohschneider M, Budka H (2005) Subcellular localization of disease associated prion protein in the human brain. Am J Pathol 166: 287-294
- Kovács GG, Head MW, Hegyi I, Bunn TJ, Flicker H, Hainfellner JA, McCardle L, László L, Jarius C, Ironside JW, Budka H (2002) Immunohistochemistry for the prion protein: comparison of different monoclonal antibodies in human prion disease subtypes. Brain Pathol 12: 1-11
- Hainfellner JA, Brantner-Inthaler S, Cervenáková L, Brown P, Kitamoto T, Tateishi J, Diringer H, Liberski PP, Regele H, Feucht M, Mayr N, Wessely P, Summer K, Seitelberger F, Budka H (1995) The original Gerstmann-Sträussler-Scheinker family of Austria: divergent clinicopathological phenotypes but constant PrP genotype. Brain Pathol 5: 201-211
