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8th CJD Family Conference

Saturday, July 17th 2010

Presentations:

  • Conference Welcome, Florence Kranitz
  • The diagnostic process in CJD, RG Will
  • Current State of Human Prion Diagnostics, Jiri G. Safar
  • Human Prion Vaccination and other Prion Therapeutic Approaches, Thomas Wisniewski
  • Doxycycline Clinical Trial Update, Fabrizio Tagliavini
  • The national prion monitoring cohort, Simon Mead
  • The National Prion Disease Pathology Surveillance Center USA in 2010, Pierluigi Gambetti
  • PRION DISEASE SURVEILLANCE IN THE UK, Richard Knight
  • Surveillance for CJD in China and characteristics of some fCJDs, Xiao-Ping Dong
  • Surveillance in France, Jean-Philippe Brandel


Conference Welcome

Length: 8 min (Chaptered) - Presenter: Florence Kranitz

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The diagnostic process in CJD

Length: 24 min (Chaptered) - Presenter: RG Will

 

  • SOURCE OF REFERRALS TO NCJDSU FROM THROUGHOUT THE UK 1 MAY 1990 – 29 AUGUST 2008 (n=2358)
  • NUMBER OF REFERRALS TO THE NCJDSU & UK sCJD CASES 1996-2009
  • Diagnosis in ‘not CJD’ cases
  • ...

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Current State of Human Prion Diagnostics

Length: 21 min (Chaptered) - Presenter: Jiri G. Safar

 

  • Acknowledgments
  • Reservoirs of scrapie and CWD in the context of vCJD, BSE, and iCJD call for methodical prion surveillance
  • Clinical criteria for probable sCJD
  • ...

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Human Prion Vaccination and other Prion Therapeutic Approaches

Length: 22 min (Chaptered) - Presenter: Thomas Wisniewski

 

  • CONFORMATIONAL DISORDERS
  • Potential Non-Immune Treatments for Prion Disease
  • Therapeutic Approaches
  • ...

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Doxycycline Clinical Trial Update

Length: 19 min (Chaptered) - Presenter: Fabrizio Tagliavini

 

  • Tetracycline and Doxycycline
  • Tetracyclines affect prion infectivity
  • The efficacity of tetracyclines in peripheral and intracerebral prion infection
  • ...

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The national prion monitoring cohort

Length: 19 min (Chaptered) - Presenter: Simon Mead

 

  • The national prion clinic
  • Clinical work prompts questions…
  • Learning from Prion-1 Optimising a prion disease clinical trial
  • ...

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The National Prion Disease Pathology Surveillance Center USA in 2010

Length: 29 min (Chaptered) - Presenter: Pierluigi Gambetti

 

  • National Prion Disease Pathology Surveillance Center Tests Performed
  • National Prion Disease Pathology Surveillance Center Cases Examined1 (April 30, 2010)
  • 14-3-3 CSF Samples Examined
  • ...

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PRION DISEASE SURVEILLANCE IN THE UK

Length: 16 min (Chaptered) - Presenter: Richard Knight

 

  • outline
  • PRION DISEASES IN THE UK
  • UK CJD SURVEILLANCE & CLINICAL RESEARCH
  • ...

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Surveillance for CJD in China and characteristics of some fCJDs

Length: 25 min (Chaptered) - Presenter: Xiao-Ping Dong

 

  • CJD surveillance network
  • CJD surveillance methodology
  • Case definition
  • ...

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Surveillance in France

Length: 17 min (Chaptered) - Presenter: Jean-Philippe Brandel

 

  • Surveillance - Historical data
  • French surveillance network of Creutzfeldt-Jakob Disease and other Transmissible Spongiform Encephalopathies
  • ...

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Sunday, July 18th 2010

Presentations:

  • Report on status of database and data collection, Carlos Alzola
  • The Centers for Disease Control and Prevention Report: Prion Disease Activities at CDC, Ryan A. Maddox
  • Searching for Custom Dominant Negative PrPs by In Vitro Prion Replication Studies, Joaquín Castilla
  • Is protease-sensitive prionopathy (PSPr) the sporadic form of Gerstmann-Sträussler-Scheinker disease (GSS)? Preliminary data, Gianfranco Puoti
  • Adult Neurogenesis in Prion Diseases: A New Lead for Therapeutics?, Sylvain Lehmann
  • PrioNet Canada, Neil Cashman
  • Alberta Prion Research Institute, Kevin Keough
  • Reducing TSE Risk from Biologicals by Removal, Robert G. Rohwer


Report on status of database and data collection

Length: 21 min (Chaptered) - Presenter: Carlos Alzola

 

  • Summary
  • Summary (cont.)
  • Demographics
  • ...

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The Centers for Disease Control and Prevention Report: Prion Disease Activities at CDC

Length: 20 min (Chaptered) - Presenter: Ryan A. Maddox

 

  • Objective
  • Surveillance
  • What is surveillance?
  • ...

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Searching for Custom Dominant Negative PrPs by In Vitro Prion Replication Studies

Length: 21 min (Chaptered) - Presenter: Joaquín Castilla

 

  • The problem
  • The data
  • The solution
  • ...

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Is protease-sensitive prionopathy (PSPr) the sporadic form of Gerstmann-Sträussler-Scheinker disease (GSS)? Preliminary data

Length: 17 min (Chaptered) - Presenter: Gianfranco Puoti

 

  • A novel human disease with abnormal prion protein sensitive to protease
  • Comparative study of GSS and PSPr
  • ...

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Adult Neurogenesis in Prion Diseases: A New Lead for Therapeutics?

Length: 14 min (Chaptered) - Presenter: Sylvain Lehmann

 

  • What is adult neurogenesis, generation of new neurons
  • New neural stem cells in rodent and human brain
  • Physiological situation
  • ...

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PrioNet Canada

Length: 12 min (Chaptered) - Presenter: Neil Cashman

 

  • BSE in North America
  • Variant CJD: Secondary Epidemics?
  • Chronic Wasting Disease
  • ...

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Alberta Prion Research Institute

Length: 17 min (Chaptered) - Presenter: Kevin Keough

 

  • The Problem
  • Five Years Ago
  • Canadian Prion Network
  • ...

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Reducing TSE Risk from Biologicals by Removal

Length: 14 min (Chaptered) - Presenter: Robert G. Rohwer

 

  • Blood or urine based diagnostics
  • Protection of blood and other biologicals
  • Advantages of Removal
  • ...

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